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当前位置: 首页 > 产品中心 > cell_proliferation > Innoprot/绿色荧光BACE1细胞系/P30700
商品详细Innoprot/绿色荧光BACE1细胞系/P30700
Innoprot/绿色荧光BACE1细胞系/P30700
Innoprot/绿色荧光BACE1细胞系/P30700
商品编号: P30700
品牌: Innoprot
市场价: ¥39.90
美元价: 19.95
产地: 美国(厂家直采)
公司:
产品分类: 细胞增殖
公司分类: cell_proliferation
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Beta-secretase 1 (BACE1), a.k.a. beta-site amyloid precursor protein cleaving enzyme 1 or beta-site APP cleaving enzyme 1, is an enzyme and BACE1 gene encodes it in humans. BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. Innoprot has developed a family of green fluorescent BACE1 stable Cell lines for cell-based assays applications.

The pathogenesis of Alzheimer’s disease is highly complex. While several pathologies characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark neuropathological lesions in Alzheimer’s disease brain. Indeed, a wealth of evidence suggests that β-amyloid is central to the pathophysiology of AD and is likely to play an early role in this intractable neurodegenerative disorder. The BACE1 enzyme is essential for the generation of β-amyloid. The fact that BACE1 initiates the formation of β-amyloid, and the observation that BACE1 levels are elevated in this disease provide direct and compelling reasons to develop therapies directed at BACE1 inhibition thus reducing β-amyloid and its associated toxicities. Recent studies show that complete abolishment of BACE1 provokes specific behavioral and physiological alterations.

  • Reference: P30700
  • Size/Quantity: 1 vial containing 3x106 cells / vial
  • Product Use: For research use only
  • Shipping Conditions: Dry Ice
    • Data Sheet
    品牌介绍
    Innoprot是一家生物技术公司,成立于2007年,是巴斯克地区大学的附属公司。Innoprot提供产品和技术,用于在药物发现和开发中对基于细胞的测定进行多路复用,包括原代细胞,永生细胞系和重组细胞系。凭借专有的GPCR筛选技术,Innoprot能够鉴定具有最高效力的化合物,同时避免了不良副作用。Innoprot还担任CRO,提供针对GPCR,纤维化和神经退行性疾病(例如阿尔茨海默氏病,帕金森氏病或ALS)的筛查服务。Inno prot的私人员工将药物发现技术领域的经验与制药服务提供商广泛的职业道路相结合。